Growth Hormone and Endothelial Function in Children
Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
Objective: This study is designed to determine whether growth hormone treatment in children 8
to 18 years of age alters function of the lining of the arteries. This may play a role in
increasing or decreasing the risk of heart disease.
Methods. Twenty children, for whom growth hormone therapy will be otherwise provided, will be
studied before and 3 months after starting growth hormone. Subjects can be on other hormonal
replacements but no other medications.
Each study will be done in the fasting state. The blood vessel function will be determined by
measuring the change in forearm blood flow before and after blocking flow to the arm for 5
minutes. Blood will be drawn after the test to measure glucose, insulin and fats.