Group Cognitive Behavioral Therapy Versus Fluoxetine for Obsessive-Compulsive Disorder: a Practical Trial
Status:
Completed
Trial end date:
2008-09-01
Target enrollment:
Participant gender:
Summary
First line treatments fo Obsessive Compulsive Disorder (OCD) are Selective Serotonin
Recapture Inhibitors (SSRIs) and Cognitive Behaviour Therapy (CBT) including exposure with
response prevention. The aim of the present study is to evaluate the clinical efficacy of
GCBT and SSRIs for OCD patients. Other clinical trials have compared these treatments, but
with OCD patients without any other psychiatric disorder. In this study patients with current
age between 18 and 65 years, with YBOCS score of at least 16 and psychiatric comorbidities
will be not excluded. Exclusion criteria will be: OCD secondary to brain trauma, stroke or
malformation; current abuse of alcohol or other psychoactive substance, current presence of
psychotic symptoms, suicidal risk, psychiatric or clinical comorbidity that might get worse
with the medications used in the trial. So, the present study investigates the efficacy of
these treatments for a heterogeneous OCD population, trying to identify if the usual
treatments are efficient when applied in the public health system that treat not just
patients with only OCD diagnosis. Patients will be randomized for GCBT and SSRI, and after
treatment will be evaluated by researchers blind to the treatment received.
Phase:
Phase 4
Details
Lead Sponsor:
University of Sao Paulo
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo