RATIONALE: Green tea extract contains ingredients (catechins) that may lower the risk of
breast cancer.
PURPOSE: This phase II trial is studying how well green tea extract works in preventing
breast cancer compared to a placebo in postmenopausal women with high breast density.
The investigators have hypothesized that green tea consumption reduces breast cancer risk,
and this effect is seen primarily in women who have the low-activity COMT genotype. The
investigators will test this by evaluating the effects of green tea extract on breast cancer
biomarkers including mammographic density, plasma insulin-like growth factor 1 (IGF-1), IGF
binding protein 3 (IGFBP-3), estrone, estradiol, androstenedione, sex hormone binding
globulin (SHBG), urinary estrogen metabolites and plasma F2-isoprostanes.
Phase:
Phase 2
Details
Lead Sponsor:
University of Minnesota University of Minnesota - Clinical and Translational Science Institute