Granisetron vs Granisetron and Dexamethasone on the Reduction of Postoperative Nausea and Vomiting
Status:
Recruiting
Trial end date:
2021-06-01
Target enrollment:
Participant gender:
Summary
Intrathecal morphine (ITM) has proven to be excellent in reducing postoperative pain.
However, its use has commonly been associated with the occurrence of postoperative nausea and
vomiting (PONV). In recent years, the combination therapy of antiemetics comprising of a
serotonin receptor antagonist and corticosteroid has been implemented to diminish the
occurrence of PONV. Despite being routinely used, the evidence in the efficacy of this
combination in parturients are conflicting and lacking. In this study, we wish to compare the
efficacy between the combination therapy of granisetron plus dexamethasone versus granisetron
alone on the occurrence of postoperative nausea and vomiting (PONV) in 126 parturients
undergoing elective Caesarean delivery supplemented with intrathecal morphine.