Granisetron Transdermal Patch for Prevention of Postoperative Nausea and Vomiting
Status:
Completed
Trial end date:
2018-02-19
Target enrollment:
Participant gender:
Summary
The objective of the study is to evaluate the efficacy and safety of adding transdermal
preparation of granisetron (Sancuso ®) to the current postoperative nausea and vomiting
(PONV) standard prophylaxis regimen with dexamethasone and ondansetron in patients with the
previous history of severe, particularly delayed and/or post-discharge, PONV and undergoing
surgical procedure under general anesthesia.
The specific aims of the study include:
1. efficacy of the investigated therapy in prevention of PONV up to 120 hours after surgery
2. incidence and seriousness of the observed side effects
3. ability of patients to self-administer preoperatively and maintain the investigated
patch during the perioperative period
4. level of satisfaction with the preoperative PONV prophylaxis.