Overview

Granisetron Transdermal Patch System for Prevention of CINV by CapeOX

Status:
Recruiting
Trial end date:
2023-06-01
Target enrollment:
0
Participant gender:
All
Summary
This study aims to explore the prevention of delayed chemotherapy induced by CAPOX regimen with granisetron transdermal patch。
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Tianjin Medical University Cancer Institute and Hospital
Treatments:
Granisetron
Criteria
Inclusion Criteria:

- Male or female, aged >18 years.

- Eligible patients were diagnosed with a colorectal malignancy and scheduled to receive
chemotherapy of CapeOx regimens.

- The Eastern Cooperative Oncology Group Performance Status (ECOG PS) scores of patients
were between 0 and 2.

- Patients with life expectancy≥6 months.

- Patients with the ability to understand the study and are willing to sign written
informed consent document.

- Patients who were able to read, understand and follow the study procedures,and
completed the questionnaire unaided.

Exclusion Criteria:

- Patients with metabolic and haematological abnormalities who are unsuitable for
chemotherapy. The following criteria are included: (1) Abnormal of blood routine:
absolute neutrophil count(ANC) <1.5*109/L,white blood cell count (WBC)<3.0*109/L,
platelet count (PLT) <100*109/L or hemoglobin (HB)<100g/L;(2) Abnormal liver function:
aspartate aminotransaminase (AST) and/or aspartate aminotransferase (ALT)≥2.5*ULN,
bilirubin is greater than 1.5 times the upper limit of normal value (ULN). In patients
with known liver metastasis: AST is greater than or equal to 5 times the upper limit
of normal value (ULN); ALT is greater than or equal to 5 times the upper normal value
(ULN); (3) Abnormal renal function: serum creatinine is greater than 1.5*ULN.

- Patient had symptomatic primary or metastatic central nervous system malignancies.

- Patient used any drug with potential antiemetic effect within 7 days before receiving
chemotherapy: 5-HT3 receptor antagonist (such as granisetron), phenothiazide (such as
chlorpromazine), phenylbutanone (such as haloperidol), benzamide (such as
metoclopramide), domperidone, cannabinoids, herbal medicine with potential antiemetic
effect, anisodamine, seclizine, etc.

- Patients began to receive benzodiazepines or opioids within 48 hours before the first
day of the study (except for single daily use of triazolam, temazepam or midazolam).

- Patients shall not receive any dose of systemic glucocorticoid treatment within 72
hours before the first day, except as specified in the protocol.

- Patients with historical or predisposing cardiac conduction abnormalities (such as
torsade de pointe, ventricular tachycardia, long QT interval syndrome, or others),
excluding incomplete right bundle branch block.

- Patients with severe cardiovascular diseases include acute myocardial infarction,
unstable angina pectoris, significant membranous or pericardial disease, history of
ventricular tachycardia, symptomatic chronic heart failure (New York Heart Association
[NYHA] class III-IV) and uncontrolled hypertension.

- Patients with severe emotional or mental disorders.

- Patients are taking or has used the following CYP3A4 inducers within 30 days before
the first day of treatment, which will affect the efficacy of therapeutic drugs
according to the evaluation of the researcher.

- Patients are taking or has used the following CYP3A4 substrates and inhibitors within
7 days before the first day of treatment, which will significantly increase the
adverse events related to therapeutic drugs according to the evaluation of the
investigator.

- Patients with active phase infection (e.g. pneumonia) or any uncontrolled disease
(such as diabetic ketoacidosis or gastrointestinal obstruction), researchers believe
that treatment may confuse research results or lead to uncertainty risk.

- Pregnant women, lactating women, or women of childbearing age with positive blood
and/or urine HCG test results before the test. Male and female subjects did not take
effective contraceptive measures, or planned to be pregnant within 6 months after the
start of the trial.

- Patients have any medical history that the investigator believes may confound the
results of the study or expose the patient to unnecessary risks.