Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy
Status:
Completed
Trial end date:
2018-12-26
Target enrollment:
Participant gender:
Summary
Propofol is one of the most commonly used anesthetic agents because of its ability to induce
rapid and reliable collection. However, hypotension and injection pain in the induction are
the most common complications. After induction of propofol; The cardiovascular system
depresses, resulting in a drop in blood pressure due to decreased cardiac output and systemic
vascular resistance. This may also contribute to the reduction of sympathetic tone activity
in the central way, and slight reduction in the number of pulses that develop as a result of
increasing vagal activity. İn order to attenuate these hemodynamic undesired effects caused
by propofol, various agents were tried such as atropine, ephedrine, volume replacement ringer
lactate, ketamine. Ondansetron and granisetron, which are used for postoperative nausea and
vomiting prophylaxis, have been used as such. Therefore, ondansetron and granisetron were
preventing hypotension induced by post-spinal and general anesthesia induction.
The investigator also tried to demonstrate the effect of granisetron, another serotonin type
3 (5-HT3) receptor antagonist for postoperative nausea and vomiting prophylaxis, on induction
hypotension and intubation quality after propofol induction in this study
Phase:
Phase 4
Details
Lead Sponsor:
Diskapi Yildirim Beyazit Education and Research Hospital