Gradual Withdrawal of Remifentanil Infusion Reduced Postoperative Pain and Opioid Requirement During Breast Surgery

• Status: Completed
• Trial end date: 2019-07-03
• Target enrollment: 0
• Participant gender: Female

Summary

Although remifentanil provides profound analgesia during operation, postoperative occurrence of hyperalgesia and tolerance after remifentanil administration could be a challenge to the postoperative pain control. Evaluation of analgesia and anti-nociception during anesthesia is still a challenging issue. Surgical Pleth Index (SPI) is a non-invasive and simple access tool used to monitor autonomous nervous system during anesthesia. This technique is based on photoplethysmographic wave and heart beat analysis. SPI values range between 0 (no stress) and 100 (high stress level). The purpose of this study was to determine the appropriate use of Remifentanil for pain control in patients with SPI.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Samsung Medical Center
• Treatments: Analgesics, Opioid; Remifentanil

Criteria

Inclusion Criteria:

• Patients who received the breast conserving surgery

Exclusion Criteria:

• Patients with arrhythmia who have poor SPI measurement

• When the patient refused

• Patients with decreased renal function of Cr> 2

• Surgery for more than 3 hours, surgery expected to bleed more than 500 ml