Gonyautoxins Local Periarticular Injection for Pain Management After Total Knee Arthroplasty

• Status: Unknown status
• Trial end date: 2017-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to demostrate the eficcacy in pain control management after total knee arthroplasty of Gonyautoxin. Local administration during surgery of Gonyautoxin before wound closure can achieved better pain control and lower morphin use during hospital stay compared to local administration of chirocaine, ketorolac and epinephrine

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: maximiliano barahona vasquez
• Treatments: Epinephrine; Epinephryl borate; Ketorolac; Ketorolac Tromethamine; Levobupivacaine; Racepinephrine

Criteria

Inclusion Criteria:

• Patients who required total knee arthroplasty due to knee osteoarthritis ( Kellgren and Lawrence score of 2 or more), with no response to conservative management.

• Without known allergies to the drugs used in the study

• Anesthetic risk: ASA Score 1,2,3.

Exclusion Criteria:

• Obesity, defined as body Mass index over 35

• Previous Knee surgery

• Mellitus diabetes

• Organic brain damage

• Rheumatic Arthritis

• Coagulation deficit

• Liver disease

• Chronic obstructive pulmonary disease

• Chronic consumption of opiods

• Refusal to participate in the study