Objective To assess the the efficacy of luteal support with GnRH agonist in patients
undergoing IVF in antagonist-based hcg triggered cycles compared with standard luteal support
with progesterone.
Design prospective randomized controled study Subjects Patients who underwent
antagonist-based cycles performed in the "Shaare Zedek Medical Center" IVF clinic between
2020 and 2022 Intervention Intranasal GnRH-agonist or vaginal Progesterone for luteal
support.
Main outcome measures Pregnancy and clinical pregnancy rates, ohss.
The study cohort included 150 patients who underwent 164 cycles. A total of 127 cycles were
included. Of them, 64 were treated with GnRH-a and 63 with progesterone.
Hypothesis: This RCT suggests that GnRH-a for luteal phase support is associated with a
higher positive β-hCG pregnancy rate and clinical pregnancy rate, compared with standard
progesterone support in an antagonist-based protocol triggered with hCG, while maintaining a
similar safety profile.