GnRH Agonist and Progesterone Versus Progesterone Only for Luteal Phase Support in Antagonist Cycles
Status:
Unknown status
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
In-Vitro Fertilisation (IVF) is the term commonly applied to a form of treatment for
infertility that involves controlled ovarian hyperstimulation, egg maturation, egg
collection, fertilisation, embryo culture and finally embryo transfer. The period after egg
collection is called luteal phase. In Australia, vaginal progesterone is routinely used to
support the lining of the uterus so that it is susceptible to implantation of the embryos.
More recently, there has been some suggestion that additional supplementation of luteal phase
with GnRH agonist increases clinical pregnancy and live birth rate. These studies are however
heterogeneous and results were inconsistent.
This study is a prospective randomised controlled trial of additional GnRH agonist in luteal
phase of antagonist cycle. The primary hypothesis is that GnRH agonist increases the number
of live birth . The secondary hypothesis is that this increases the clinical pregnancy rate,
on-going pregnancy rate, without affecting the miscarriage rate, ovarian hyperstimulation
rate and multiple pregnancy rate.