GnRH Agonist Versus hCG Trigger in Ovulation Induction With Intrauterine Insemination.

• Status: Completed
• Trial end date: 2017-06-30
• Target enrollment: 0
• Participant gender: Female

Summary

This study aims to compare clinical pregnancy rates (CPR) in patients who are administered either Gonadotropin-releasing hormone agonists (GnRHa) or human chorionic gonadotropin (hCG) for ovulation trigger in intrauterine insemination (IUI) cycles. A prospective randomized comparative study was conducted at Hue University Hospital in Vietnam. Total of 197 infertile women were randomly assigned to receive either GnRHa trigger (n=98 cycles) or hCG trigger (n= 99 cycles) for ovulation trigger. Patients returned for ultrasound monitoring 24 hours after IUI to confirm ovulation. A clinical pregnancy was defined as the presence of gestational sac with fetal cardiac activity.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hue University of Medicine and Pharmacy
• Treatments: Chorionic Gonadotropin; Deslorelin

Criteria

Inclusion Criteria:

• Infertile women who were indicated for IUI cycles

• bilateral tubal patency

• at least one follicle ≥ 18mm in diameter on the day of trigger, and

• men with more than five millions total motile sperm after preparation.

• Only the first cycles of IUI were studied

Exclusion Criteria:

• No mature follicle

• Disagree to be enrolled