Glycerin Suppositories to Reduce Jaundice in Premature Infants

• Status: Completed
• Trial end date: 2013-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to find out if giving glycerin suppositories will help decrease the length of time premature infants need phototherapy.

The investigators hypothesize that glycerin suppositories (initiated along with phototherapy) will have no effect on reducing duration of phototherapy in premature infants with jaundice.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Rochester
• Treatments: Glycerol

Criteria

Inclusion Criteria:

1. Baby born between 30 to 34 6/7 weeks gestational age (GA) at birth and admitted to NICU

2. Baby with physiologic hyperbilirubinemia requiring phototherapy by current NICU criteria.

3. Parental permission.

Exclusion Criteria:

1. Babies less than 30 weeks GA or greater than 34 6/7 weeks GA

2. Non-physiologic hyperbilirubinemia: (1) positive Coombs test and (2) hematocrit < 5th percentile for GA (see Jopling J, Henry E, Wiedmeier SE, Christensen RD, Reference. Ranges for Hematocrit and Blood Hemoglobin Concentration During the Neonatal Period: Data From a Multihospital Health Care System. Pediatrics 2009; 123(2):e333 -e337.) and (3) ABO or Rh incompatibility.

3. Any infant with bilirubin level within 2 mg/dL of exchange transfusion.

4. Any infant who has phototherapy started prior to reaching light level (prophylactic)

5. Baby with any GI abnormalities such as NEC, intestinal perforation, gastroschisis, omphalocele, malrotation and or volvulus, duodenal atresia, intestinal strictures/adhesions, imperforate anus.

6. Any infant begun on triple or greater phototherapy at time of initiation of treatment.

7. Any infant judged by the attending physician to be placed at increased risk by study participation.