Glycemic Response to Momordica Charantia in Type 2 Diabetes

• Status: Withdrawn
• Trial end date: 2009-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Diabetes is a common disease which has been treated by traditional medicines for centuries before modern medicine became available. A very common remedy for Diabetes Mellitus in different cultures is momordica charantia (karela or Bitter gourd). The use of alternative medicine is common among Pakistani population. This study was planned to find out the effect of administering freeze dried powder of momordica charantia for three weeks on the glycemic profile and insulin resistance of treatment naiive patients with mild Type 2 diabetes.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Services Hospital, Lahore
• Collaborator: University of the Punjab

Criteria

Inclusion Criteria:

1. Adult Type 2 diabetics with mild degree of hyperglycemia (FBG >126<200 mg/dl)

2. Absence of serious co-morbid conditions

3. Patients agreeing to participate in this trial

Exclusion Criteria:

1. Type 1 diabetics

2. Pregnancy

3. Paediatric age group

4. Patients known to be allergic to Momordica charantia

5. Serious cardio-respiratory illness, previous myocardial infarction, angina pectoris, heart failure, uncontrolled hypertension ≥ stage 2, COPD, asthma, active pulmonary tuberculosis

6. Significant hepatic impairment: ALT >60, Bilirubin >2 mg/dl

7. Significant renal impairment: S/creatinine >1.5 mg/dl, albuminuria > 1+

8. Patients with conditions likely to interfere with the absorption of the trial therapy:

malabsorption, chronic diarrhoea, intestinal resection, blind loop syndrome

9. Patients withholding consent

10. Patients, both male and female, desiring pregnancy during the trial phase.

11. Secondary causes of diabetes

12. Patients using drugs influencing glucose metabolism: steroids, hormonal contraception, menopausal HRT , diazoxide, phenytoin, colchicine