Glutathione Levels and Compulsivity

• Status: Completed
• Trial end date: 2017-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

The investigators will examine whether compulsivity in those who score above-average (but below clinical cut-off) on an eating disorder questionnaire can be altered by 9 days of N-acetyl cysteine (NAC). N-acetyl cysteine has been shown to be of some benefit in individuals with other compulsive disorders, such as trichotillomania and addiction, so this research investigates whether a short period of time taking N-acetyl cysteine changes compulsivity, measured using cognitive tasks and questionnaires.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oxford
• Treatments: Acetylcysteine; N-monoacetylcystine

Criteria

Inclusion Criteria:

• Participant is willing and able to give informed consent for participation in the study.

• Females aged 18 to 40 years.

• Score between 9 and 19 on the EAT-26.

• Participant is a fluent English speaker

Exclusion Criteria:

• Any current psychotropic medications.

• Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the study.

• BMI below 18.5, indicating that they are underweight.

• Any Axis I psychiatric disorder.

• History of allergies to drugs or vaccines or any component of the NAC or placebo capsule (gelatine, magnesium stearate, NAC).

• Pregnant, could be pregnant, breast feeding, or high risk of pregnancy (no reliable contraception use but sexual activity).

• Has taken part in a psychological or medical experiment involving taking any kinds of drugs within the last 6 weeks.

• Has had recent surgery.

• Taking selenium, vitamin E, or NAC.

• Current regular cigarette smoking of over 5 cigarettes per day.