Glutamate for Metabolic Intervention in Coronary Surgery

• Status: Completed
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The main purpose of this study is to determine whether intravenous glutamate infusion given in association with surgery for unstable coronary artery disease can protect the heart from myocardial injury, postoperative heart failure and death.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Linkoeping
• Collaborators: Blekingesjukhuset, Karlskrona; Region Örebro County
• Treatments: Anesthetics; Tin Fluorides

Criteria

Inclusion Criteria:

• surgery for unstable coronary artery disease (unstable angina, non-STEMI)

• accepted for surgery < 2 weeks after STEMI

• coronary surgery for indications above performed with or without cardiopulmonary bypass

• coronary surgery for indications above with or without simultaneous valve procedure

Exclusion Criteria:

• informed consent not possible because of critical condition or other reason

• preoperative use of inotropes or mechanical circulatory assist

• preoperative dialysis

• redo-procedure

• unexpected intraoperative finding / event that increased the dignity of the procedure to overshadow the originally planned operation

• body weight > 125 kg

• food allergy known to have caused flush, rash or asthma