Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine
Status:
Recruiting
Trial end date:
2023-05-01
Target enrollment:
Participant gender:
Summary
The overarching aim of this research is to determine the acute effects of ketamine on brain
glutamate, functional connectivity and cerebral blood flow in treatment-resistant depression,
explore whether the effects are attenuated by the opioid receptor antagonist naltrexone and
relate these findings to antidepressant response.