This study will determine whether glucosamine, chondroitin sulfate and/or the combination of
glucosamine and chondroitin sulfate are more effective than placebo and whether the
combination is more effective than glucosamine or chondroitin sulfate alone in the treatment
of knee pain associated with osteoarthritis (OA) of the knee after six months of follow-up.
These substances, marketed in the United States as dietary supplements, have been widely
touted by the lay press and by anecdotal personal experience as effective in treating OA. To
date, however, only a few small studies have been published in the worldwide literature. The
study proposed herein has been carefully constructed to definitively determine the efficacy
of these agents.
Phase:
Phase 3
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development
Collaborators:
National Center for Complementary and Integrative Health (NCCIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)