Glittre ADL-test: Responsiveness to Acute Bronchodilation in Chronic Obstructive Pulmonary Disease (COPD)
Status:
Unknown status
Trial end date:
2019-06-15
Target enrollment:
Participant gender:
Summary
This project is aimed to assess the responsiveness of the Glittre ADL-test and the 1-Minute
Sit-to-Stand test (1-Minute STST) to acute bronchodilation in patients with COPD. We also aim
to investigate the physiological and perceptual response to bronchodilation of the Glittre
ADL-test and the 1-minute STST. The specific objectives are 1)To measure the changes in time
for completion of the Glittre ADL-test and the number of standing up during the 1-minute STST
induced by a single dose of nebulized ipratropium bromide/salbutamol sulfate against those
induced by a placebo in patients with moderate to severe COPD and 2)To compare in patients
with moderate to severe COPD the CR (minute ventilation (VE), oxygen uptake (VO2), carbon
dioxide production (VCO2) and heart rate) and symptomatic (dyspnea and leg fatigue
perception) responses during the Glittre ADL-test and the 1-Minute STST following a single
dose of ipratropium bromide/salbutamol sulfate or placebo. We suppose among others that the
Glittre test completion time will be lesser, that the number of repetitions in the 1-Minute
STST will be higher and symptoms intensity will be lesser among patients with COPD receiving
bronchodilators.
Phase:
N/A
Details
Lead Sponsor:
Laval University
Collaborator:
Institut Universitaire de Cardiologie et Pneumologie de Québec