Glioblastoma Treatment With Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated Patients
Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to obtain first, exploratory information on the safety and
efficacy of (i) olaptesed pegol in combination with radiation therapy in patients with newly
diagnosed glioblastoma of unmethylated MGMT promoter status either not amenable to resection
(biopsy only) or after incomplete tumor resection, (ii) olaptesed pegol in combination with
radiation therapy and bevacizumab in patients with newly diagnosed glioblastoma of
unmethylated MGMT promoter status either not amenable to resection (biopsy only) or after
incomplete tumor resection and (iii) olaptesed pegol in combination with radiation therapy in
patients with newly diagnosed glioblastoma of unmethylated MGMT promoter status after
complete tumor resection.