Overview

Glibenclamide Advantage in Treating Edema After Intracerebral Hemorrhage

Status:
Completed
Trial end date:
2020-09-23
Target enrollment:
0
Participant gender:
All
Summary
The purpose of the present study is to explore the efficacy of small doses of oral glibenclamide on brain edema after acute primary intracerebral hemorrhage (ICH), and improving the prognosis of patients.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Xijing Hospital
Treatments:
Glyburide
Imidacloprid
Criteria
Inclusion Criteria:

1. Age 18-70 years with a primary ICH

2. A baseline CT with basal ganglia hemorrhage of 5 to 30 mL

3. Glasgow Coma Scale (GCS) score ≥ 6

4. Symptom onset less than 72 hours prior to admission

5. Informed consent

Exclusion Criteria:

1. Supratentorial ICH planned to evacuation of a large hematoma

2. Hemorrhage breaking into ventricles of brain

3. Prior significant disability (mRS ≥ 3)

4. Severe renal disease (i.e., renal disorder requiring dialysis ) or eGFR
<30ml/min/1.73m2

5. Severe liver disorder, or ALT >3 times or bilirubin >2 times upper limit of normal

6. Blood glucose < 55 mg/dL (3.1 mmol/L）at enrollment, or with the history of
hypoglycemia

7. With acute ST elevation infarction, or decompensated heart failure, or cardiac arrest,
or acute coronary syndrome, or known history of admission for acute coronary syndrome,
or acute myocardial infarction, or coronary intervention in the past 3 months

8. Treatment with sulfonylurea in the past 7 days, including glyburide, glyburide plus
metformin, glimepiride, repaglinide, glipizide, gliclazide, tolbutamide and
glibornuride

9. Treatment with bosentan in the past 7 days

10. Be allergic to sulfa or other sulfonylurea drugs

11. Known G6PD deficiency

12. Pregnant women

13. Breast-feeding women disagreeing to participate the study or stop breastfeeding during
and after the study

14. Be enrolled in other non-observation-only study with receiving an investigational drug

15. Refusing to be enrolled, or having poor compliance, or tending to withdraw