Overview

Giving Gene Marked EBV Specific T-Cells to Patients Receiving a BMT for Relapsed EBV-Positive Hodgkin Disease

Status:
Terminated
Trial end date:
2006-08-01
Target enrollment:
0
Participant gender:
All
Summary
Subjects have a type of lymph gland cancer called Hodgkin or non-Hodgkin Lymphoma, which has come back or not gone away after treatment, including the best treatment we know for relapsed Lymphoma. We are asking subjects to volunteer to be in a research study using Epstein Barr virus (EBV) specific cytotoxic T lymphocytes, a new experimental therapy. This therapy has never been used in patients with Hodgkin disease or this type of non-Hodgkin Lymphoma but it has been used successfully in children with other types of blood cancer caused by EBV after bone marrow transplantation. Some patients with Hodgkin disease or non-Hodgkin Lymphoma show evidence of infection with the virus that causes infectious mononucleosis Epstein Barr virus (EBV) before or at the time of their diagnosis of Lymphoma. EBV is often found in the cancer cells suggesting that it may play a role in causing Lymphoma. The cancer cells infected by EBV are very clever because they are able to hide from the body's immune system and escape destruction. We want to see if we can grow special white blood cells, called T cells, that have been trained to kill EBV infected cells and give them back to subjects.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Baylor College of Medicine
Collaborators:
Center for Cell and Gene Therapy, Baylor College of Medicine
Texas Children's Hospital
The Methodist Hospital Research Institute
The Methodist Hospital System
Criteria
INCLUSION CRITERIA:

- Any patient with Hodgkin disease or non-Hodgkin Lymphoma, containing the EBV genome or
antigen, receiving an autologous bone marrow transplant regardless of age or sex.

- Patients with tumor tissue EBV +ve.

- Patients with life expectancy >6 weeks.

- Patients with Karnofsky score of > 50.

- No severe intercurrent infection.

- Patient, parent/guardian able to give informed consent.

- Patient with Bilirubin <2x normal, SGOT <3x normal, and ANC greater than 500mm

- Patients with creatinine <2x normal for age or creatinine clearance >2x normal for
age.

- Patients should have been off other investigational therapy for one month prior to
entry in this study.

EXCLUSION CRITERIA:

- Patients with a life expectancy of <6 weeks.

- Patients with an EBV positive Lymphoma secondary to an acquired or congenital
immunodeficiency.

- Patients with a Karnofsky score less than or equal to 50.

- Patients with a severe intercurrent infection.

- Patients with a bilirubin >2x normal,SGOT >3x normal, or abnormal prothrombin time.

- Patients with a creatinine >2x normal for age or creatinine clearance <2x normal for
age.

- Patients with an ANC <500mm

- Patient, parent/guardian unable to give informed consent.

- Patients who have been on other investigational therapy within one month prior to
entry in this study.

- Due to unknown effects of this therapy on a fetus, pregnant women are excluded from
this research. Women of childbearing potential must be on appropriate birth control
for the duration of the study and 6 months after completion of the study. In addition,
the male partner should use a condom.