Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial
Status:
Recruiting
Trial end date:
2021-09-01
Target enrollment:
Participant gender:
Summary
Previous clinical studies have confirmed that revascularization or recanalization rate after
intravenous thrombolysis is closely related to the formation of thrombus, which also results
in poor neurological function after thrombolysis. Platelet activating factor (PAF) strong
platelet aggregation may be involved in thrombosis. Formation process. The main components of
Ginkgolide injection (Ginkgo) are ginkgolide, ginkgolides A, ginkgolides B and ginkgolides C.
Ginkgo biloba lactone can antagonize PAF and has strong anti-platelet aggregation. .
Therefore, it can be speculated that ginkgolides injection combined with alteplase
intravenous thrombolysis may improve the recanalization rate after thrombolysis and reduce
the reocclusion rate.
In addition, clinical studies have also found that ginkgolide injection has a good auxiliary
effect on hypertensive intracerebral hemorrhage, which can regulate inflammatory factors such
as IL-6, TNF-α and high-sensitivity C-reactive protein (CRP) in patients. Recovery of
neurological function in patients. It is well known that TNF-α, IL-β, IL-1, IL-6, IFN-γ, etc.
are all inflammatory factors associated with reperfusion injury. Therefore, we speculate that
ginkgolides injection may also regulate inflammatory factors associated with reperfusion
injury, such as IL-6, TNF-α, thereby reducing reperfusion injury, thereby improving patient
prognosis.
The aim of this study was to determine the clinical efficacy of ginkgolides injection
combined with alteplase in the treatment of acute ischemic stroke, and to improve the
prognosis of patients with thrombolysis.
Phase:
Phase 4
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborators:
Changxing People's Hospital Dongyang People's Hospital Haiyan People's Hospital Huzhou First People's Hospital Taizhou First People's Hospital The Central Hospital of Lishui City The Second Affiliated Hospital of Jiaxing University Tongxiang First People's Hospital Tongxiang Second People's Hospital