Ginger Control of Chemotherapy Induced Nausea and Vomiting

• Status: Completed
• Trial end date: 2007-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a trial to determine the safety and efficacy of ginger in reducing the prevalence and severity of chemotherapy induced nausea and vomiting.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Center for Complementary and Integrative Health (NCCIH)

Criteria

Inclusion criteria:

• Confirmed diagnosis of cancer and currently receiving chemotherapy

• Currently being treated with any chemotherapeutic agent at any dose, and have experienced nausea and/or vomiting from a previous round of chemothearpy

• Scheduled to receive a 5-HT3 receptor antagonist antiemetic: ondansetron (Zofran®) granistron (Kytril®), tropisetron (Navoban®) or dolasetron mesylate (Anzemet®), palanosetron (Alozi) and/or the NK1 antagonist aprepitant (Emend)

• Must be able to swallow capsules

• Must be able to understand English or Spanish, complete questionnaires in English or Spanish

• Women of childbearing age to use appropriate birth control

Exclusion criteria:

• Chemotherapy regimens with multiple-day doses

• Clinical evidence of current or impending bowel obstruction or symptomatic brain metastases

• Concurrent radiotherapy that is classified as high or intermediate risk of causing nausea and vomiting; total body irradiation, hemi-body, upper abdomen, abdominal-pelvic mantle, cranium, craniospinal irradiation

• Pregnant or lactating

• Patients with a history of a bleeding disorder(s) or those experiencing thrombocytopenia

• Currently be taking ginger or have taken ginger in the last month

• Have an allergy to ginger