German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93)

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The study evaluates the efficacy and tolerability of a risk- and subtype-adapted chemotherapy over one year, followed by randomized either intensified or conventional maintenance therapy. It includes a distinct protocol for the subgroup 'mature B-ALL',

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Johann Wolfgang Goethe University Hospital
• Collaborator: Deutsche Krebshilfe e.V., Bonn (Germany)
• Treatments: 6-Mercaptopurine; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Doxorubicin; Ifosfamide; Mercaptopurine; Methotrexate; Mitoxantrone; Prednisolone; Thioguanine; Vincristine

Criteria

Inclusion Criteria:

• Acute Lymphocytic Leukemia

• Age 15 - 65 years

Exclusion Criteria:

• Serious secondary diseases which may compromise intensified chemotherapeutical treatment

• Serious psychiatric diseases, which may compromise compliance with therapy

• HIV-1 or HIV-2 Infection

• Pretreatment > 2 weeks or chemotherapy other than Vincristine and Steroids

• Patients without central diagnosis who cannot be allocated to a risk group