Local application of antibiotics directly to the traumatic wound is a promising treatment for
the prevention of infection after open tibia fractures, which are a significant source of
disease burden globally, particularly in low-income countries. This study aims to measure the
effect of locally applied gentamicin on risk of infection for open tibial fractures in
Tanzania. If proven effective, local gentamicin would be a highly cost-effective strategy to
reduce complications and disability from open tibial fractures that could impact care in both
high- and low-income countries.
Phase:
Phase 4
Details
Lead Sponsor:
University of California, San Francisco
Collaborators:
Muhimbili Orthopaedic Institute National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Orthopedic Research and Education Foundation