Overview

Genetically Engineered Cells (COH06) With or Without Atezolizumab for the Treatment of Non-small Cell Lung Cancer Previously Treated With PD-1 and/or PD-L1 Immune Checkpoint Inhibitors

Status:
Not yet recruiting
Trial end date:
2025-01-28
Target enrollment:
0
Participant gender:
All
Summary
This phase I trial studies the side effects and best dose of COH06 with or without atezolizumab in patients with non-small cell lung cancer previously treated with PD-1 and/or PD-L1 immune checkpoint inhibitors that has spread to other places in the body (advanced) and that has not responded to previous treatment (refractory). NK cells are infection fighting blood cells that can kill tumor cells. The NK cells given in this study, COH06, will come from umbilical cord blood and will have a new gene put in them that makes them express PD-L1, and express and secrete IL-15. NK cells that express PD-L1 may kill more tumor cells, and IL-15 may allow the NK cells to live longer. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving COH06 without or without atezolizumab may help control the disease in patients with non-small cell lung cancer.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
City of Hope Medical Center
Collaborator:
National Cancer Institute (NCI)
Treatments:
Antibodies, Monoclonal
Antineoplastic Agents
Atezolizumab
Cyclophosphamide
Fludarabine
Criteria
Inclusion Criteria:

- Documented informed consent of the participant and/or legally authorized
representative

- Assent, when appropriate, will be obtained per institutional guidelines

- Agreement to allow the use of archival tissue from diagnostic tumor biopsies

- Age >= 18 years

- Eastern Cooperative Oncology Group (ECOG) 0 or 1

- Lung non-small cell carcinoma (NSCLC) patients with advanced, metastatic, or recurrent
disease, previously treated with a PD-1 or PD-L1 immune checkpoint inhibitor, either
as single agent or in combination with chemotherapy or other immunotherapy or
experimental agents

- Radiographically demonstrable tumor progression treatment on or after therapy with a
PD-1/PD-L1 immune checkpoint inhibitor

- Preserved organ function and recovery of prior drug related toxicities (except
alopecia or grade 2 anemia) to grade 1 or better

- No cytotoxic chemotherapy or immunotherapy over the three weeks prior to
lymphodepletion

- Histologically confirmed non-small cell lung cancer

- Measurable disease as per Response Evaluation Criteria in Solid Tumors (RECIST)
criteria 1.1

- Fully recovered from the acute toxic effects (except alopecia) to =< grade 1 to prior
anti-cancer therapy

- Absolute neutrophil count (ANC) >= 1,500/mm^3

- Hemoglobin (Hgb) >= 8 g/dl

- Platelets >= 100,000/mm^3

- Total bilirubin =< 1.5 x upper limit of normal (ULN)

- Aspartate aminotransferase (AST) =< 1.5 x ULN

- Alanine aminotransferase (ALT) =< 1.5 x ULN

- Alkaline phosphatase (AP) =< 1.5 x ULN

- Creatinine clearance of >= 60 mL/min per 24-hour urine test or the Cockcroft-Gault
formula

- If not receiving anticoagulants: International normalized ratio (INR) OR prothrombin
(PT) =< 1.5 x ULN

- If on anticoagulant therapy: PT must be within therapeutic range of intended use of
anticoagulants

- Seronegative for human immunodeficiency virus (HIV) antigen (Ag)/antibody (Ab) combo,
hepatitis C virus (HCV), active hepatitis B virus (HBV) (surface antigen negative)

- If positive, hepatitis C ribonucleic acid (RNA) quantitation must be performed

- Women of childbearing potential (WOCBP): Negative urine or serum pregnancy test. If
the urine test is positive or cannot be confirmed as negative, a serum pregnancy test
will be required

- Agreement by females and males of childbearing potential to use an effective method of
birth control or abstain from heterosexual activity for the course of the study
through at least 06 months after the last dose of protocol therapy

- Childbearing potential defined as not being surgically sterilized (men and women)
or have not been free from menses for > 1 year (women only)

Exclusion Criteria:

- Autologous stem cell transplant within 1 year prior to day 1 of protocol therapy

- Chemotherapy, radiation therapy, biological therapy, immunotherapy within 21 days
prior to day 1 of protocol therapy

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to study agent

- Active diarrhea

- Clinically significant uncontrolled illness

- Active infection requiring antibiotics

- Known history and/or positive serology for immunodeficiency virus (HIV) or hepatitis B
or hepatitis C infection

- Diagnosis of Gilbert's disease

- Other active malignancy

- Females only: Pregnant or breastfeeding

- Severe (grade 3 or higher) immune related adverse events during prior PD-1 inhibitor
treatment

- Any other condition that would, in the Investigator's judgment, contraindicate the
patient's participation in the clinical study due to safety concerns with clinical
study procedures

- Concomitant use of other investigational agents

- Patients with EGFR mutations or ALK translocations in their tumors, unless treatment
with the indicated tyrosine kinase inhibitor has failed

- Active brain metastases. Previously treated brain metastasis must demonstrate
stability on subsequent magnetic resonance imaging (MRI) scans

- Prospective participants who, in the opinion of the investigator, may not be able to
comply with all study procedures (including compliance issues related to
feasibility/logistics)