Genetic Variants Replication Study Associated With Dependence on Sulfonylurea in Participants With Type 2 Diabetes

• Status: Completed
• Trial end date: 2020-11-30
• Target enrollment: 0
• Participant gender: All

Summary

This study was designed to reproduce candidate single nucleotide variants found by whole exome sequencing in some type 2 diabetic patients dependent on sulfonylurea in a separate patient group. The validation of the dependence-related variations performed in this study is expected to help decision-making in the clinical use of sulfonylurea in the future.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Hypoglycemic Agents

Criteria

Inclusion Criteria:

Among patients with type 2 diabetes who visited Seoul National University Hospital endocrinology outpatient clinic, all of criteria (1)-(4) are satisfied

1. Adults over 19 years

2. More than 10 years of diabetes

3. Low dose sulfonylurea use: Equivalent capacity 2 mg or less of glimepiride

4. Less than 7.5% of glycated hemoglobin for more than 6 months

5. estimated glomerular filtration rate > 50 mL/min/1.73㎡

Exclusion Criteria:

• Type 1 diabetics

• Insulin user

• Patients diagnosed with cardiovascular disease, cancer, and other critical illness within 6 months before the study

• Patients with severe hypertension

• Patients with treatment or diseases that may have a significant effect on blood glucose levels, such as glucocorticoids and thyrotoxicosis