Genetic Sources of Variability of the Adaptation of the Ventricular Repolarisation

• Status: Completed
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The main objective is to research for genetic factors involved in the extreme modifications of the QT interval of the electrocardiogram in answer to a pharmacological stimulation (sotalol) and physiological stimulation in the apparently normal general population.

The phenotypic characterization, based on the ventricular repolarisation dynamics will be used aiming at term of the predictive genetic factors of the acquired long QT syndrome

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Sotalol

Criteria

Inclusion Criteria:

• Both sexes

• Age between 18 and 60 years

• European or North African Origin

• Body mass index between 19 and 29 kg / m ²

• Obtaining informed and written consent

Exclusion Criteria:

• Asthma

• Heart rate < 50 bpm

• Systolic blood pressure < 100 mm Hg

• Atrioventricular block

• Known chronic illness with chronic treatment

• Raynaud phenomenon

• QT prolonging drug

• Family or personal history of the congenital long QT syndrome

• QT/QTc Fridericia (QTcf) > 450 ms

• Pregnancy