Genetic Predictors of Analgesic Efficacy of Propranolol for Treating Postoperative Pain
Status:
Terminated
Trial end date:
2016-11-12
Target enrollment:
Participant gender:
Summary
This study is a randomized, double-blind, placebo controlled clinical trial. The main purpose
of this study is to determine if postsurgical pain ratings are improved with treatment with
oral Propranolol, and if the effectiveness of treatment can be modified by the presence or
absence of SNPs (Single Nucleotide Polymorphism) associated with Cathecol-O-MethylTransferase
(COMT) and mu-opioid receptor (MOR1) activity. The treatment period will last for three days
and the observation period will last for six months. Effectiveness of treatment will be
assessed by means of morphine consumption through quantitative evaluation of IV-PCA (Patient
Controlled Analgesia) morphine as primary outcome measure.
Phase:
Phase 2
Details
Lead Sponsor:
McGill University Health Center McGill University Health Centre/Research Institute of the McGill University Health Centre