Genetic Polymorphisms of ABCG2/BCRP on the Transport of Nifedipine to Breast Milk.
Status:
Unknown status
Trial end date:
2019-10-01
Target enrollment:
Participant gender:
Summary
This study aims to investigate the influence of the c.421C>A genetic polymorphism of the
ABCG2 / BCRP transporter in the concentration ratio of nifedipine in maternal milk:plasma in
hypertensive breastfeeding women attended at the Gynecology and Obstetrics Service of the
Medical School of Ribeirão Preto, of the University of São Paulo. Thus, plasma and breast
milk samples are being collected from patients in chronic use of the drug (n=30) within 15 to
30 days postnatal.