Background:
- Small differences in genes may alter responses to drugs. One gene that has different forms
is the mu opioid receptor gene. People with one form of this gene are more sensitive to
alcohol. People with a different form are sometimes more sensitive to pain. Morphine and
other prescription pain pills produce pain relief by acting at the mu opioid receptor.
Researchers want to see the effect of morphine on brain reward and subjective effects.
Morphine is a strong but short-acting pain medication that is sometimes used for anesthesia
during surgery.
Objectives:
- To compare the effect of morphine on brain measures of dopamine release using imaging.
Eligibility:
- Individuals between 21 and 55 years of age who have previously taken pain pills prescribed
to treat pain from a medical or dental procedure.
Design:
- This study has a screening phase and a study phase. The screening phase involves one or
two visits of 5 to 6 hours. The study phase consists of 4 study visits. Each study visit
will take about 8 hours.
- Participants will be screened with a medical and psychiatric history and physical exam.
They will be asked about drinking and drug-taking history, and any family history of
alcoholism or drug abuse. Blood, urine, and breath samples will be collected.
- During the first study visit, an MRI scan may be performed, questionnaires completed,
and a blood sample collected for genetic testing.
- During study visit 2, participants will test their pain sensitivity by placing one hand
in cold water. Pupil diameter will be measured after the sensitivity test. After a blood
sample is taken, participants will receive the morphine or a salt solution. The
sensitivity test and pupil diameter test will be repeated. Final blood samples will be
collected. A brief physical exam will also be performed.
- During study visits 3 and 4, participants will receive morphine or a salt solution
during a PET scan. Questionnaires to assess subjective effects will be administered.
Final blood samples will be collected. A brief physical exam will also be performed.
- Participants will stay in the clinic until the effects of the drug have worn off after
study visits 2, 3, and 4.
- About 1 week after the study session, participants will have a follow-up phone call.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)