Genetic Determinants of the Response to Salbutamol Among Asthma Patients
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The response to salbutamol varies greatly among individuals. Data from previous studies
indicate that some of the variability is accounted for by genetic polymorphisms in the gene
encoding for the adrenoceptor subtype β2. The current study was designed to evaluate
variability in the response to salbutamol among recently diagnosed patients who have not been
treated by β2 agonists or corticosteroids.
Lung function tests will be performed prior to and following a single dose administration of
salbutamol through inhalation. Additional pharmacodynamic indices will be monitored including
pulse and blood pressure. Three samples of plasma will be drawn for the evaluation of
salbutamol plasma concentration.