Genetic Basis for Variation in the Renal Elimination of Metformin
Status:
Completed
Trial end date:
2008-04-01
Target enrollment:
Participant gender:
Summary
The current study is part of a large multi-investigator grant to look at the pharmacogenetics
of a number of membrane transporters. We will study individuals with particular genotypes of
the human organic cation transporter, (hOCT2), to test the hypothesis that genetic variation
in hOCT2 is associated with variation in the renal clearance of the antidiabetic agent,
metformin.