General Plus Spinal Anesthesia and General Anesthesia Alone on Right Ventricular Function

• Status: Unknown status
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigator hypothesize that High Spinal Anesthesia (HSA) by its effect on attenuation of stress response, decrease in pulmonary vascular resistance, myocardial protection and positive myocardial oxygen balance will cause improvement in right ventricular function. So far there is no study that has evaluated the effect of HSA anesthesia on the right ventricular function, hence the investigator planned this study to compare the effect of HSA on the right ventricular function in patients with mitral valve disease with moderate to severe pulmonary hypertension planned for mitral valve replacement surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Postgraduate Institute of Medical Education and Research
• Treatments: Anesthetics; Anesthetics, General; Bupivacaine; Morphine

Criteria

Inclusion Criteria:

• 50 consecutive patients of 18 to 60 years age,

• NYHA class II or III,

• with mitral valvular disease with moderate to severe PAH (mean pulmonary artery pressure > 40 mmHg) undergoing MVR

Exclusion Criteria:

• emergency or redo surgery, patients with associated CAD or other valvular heart disease,

• COPD,

• bronchial asthma,

• obesity (BMI more than 30), anticipated difficult airway,

• opioid drug abuse or addiction and those with contraindication for spinal anaesthesia including local site infection,

• spinal deformity, deranged coagulogram defined by platelet count < 80,000 & INR > 1.