General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial

• Status: Recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a large pragmatic multicenter trial comparing maintenance of general anesthesia with total intravenous anesthesia using propofol versus volatile agent (sevoflurane, isoflurane, or desflurane) during cancer surgery. The primary endpoint is all-cause mortality.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Stony Brook University
• Treatments: Anesthetics; Anesthetics, General; Propofol

Criteria

Inclusion Criteria:

• Patients with known or suspected cancer and scheduled to undergo any of the following oncologic surgical procedures:

• Lobectomy or pneumonectomy

• Esophagectomy

• Radical (total) cystectomy

• Pancreatectomy

• Partial hepatectomy

• Hyperthermic intraperitoneal chemotherapy (HIPEC)

• Gastrectomy (subtotal or total)

• Cholecystectomy or bile duct resection

Exclusion Criteria:

• Age less than 18 years

• American Society of Anesthesiologist Class 5

• Projected life expectancy less than 30 days

• Known or suspected hypersensitivity to either propofol, e.g. egg or soy allergy, or volatile general anesthetic agents

• Known or suspected history of malignant hyperthermia