Overview

General Anesthesia for Endovascular Thrombectomy; A Pilot Study.

Status:
Unknown status
Trial end date:
2020-12-01
Target enrollment:
0
Participant gender:
All
Summary
This study evaluates the outcomes of stroke patients treated for intravascular thrombectomy, using either a local anesthetic with sedation, or a general anesthetic. Historical data will be used for those treated with the local anesthetic, and prospective data will be used for those treated with the general anesthetic.
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Saskatchewan
Collaborator:
University of Calgary
Treatments:
Anesthetics
Anesthetics, General
Anesthetics, Local
Lidocaine
Sevoflurane
Criteria
Inclusion Criteria:

- Acute ischemic stroke

- Age 18 or greater

- Onset (last seen well) time to treatment less than 12 hours

- Disabling stroke defined as a baseline NIHSS > 5 at the time of treatment

- Pre-stroke independent functional status in activities of daily living. Patient must
be living in their own home, apartment or seniors lodge where no nursing care is
required

- Pre-enrollment non-intubated state based on acceptable GCS for the prospective Cohort

- Small core proximal occlusion as confirmed by CT angiography (carotid, M1 MCA or M1
MCA equivalent)

- Intention to initiate endovascular treatment within 60 minutes of baseline
non-contrast CT

- Sevoflurane used during thrombectomy

- Appropriate consent provided

Exclusion Criteria:

- Baseline non-contrast CT reveals a moderate/large core defined as extensive early
ischemic changes of ASPECTS 0-5 in the territory of symptomatic intracranial occlusion

- Hemorrhagic stroke

- Clinical history, past imaging or clinical judgment suggests that the intracranial
occlusion is chronic

- Intubated state based on GCS at any time prior to induction of general anesthesia for
prospective cohort