General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke
Status:
Completed
Trial end date:
2020-08-01
Target enrollment:
Participant gender:
Summary
In France, the annual incidence rate of acute ischaemic stroke is around 150 000 patients, 65
% of whom keep long-term disability. Several multicentric randomized controlled trials have
shown the benefit of a mechanical thrombectomy in the acute phase of ischaemic stroke on
functional disability, compared to a medical treatment alone (thrombolysis).
The timeliness of revascularisation is an essential factor of good prognosis. This
intra-arterial treatment, associated with thrombolysis if applicable, is the reference
treatment of large-vessel occlusion. The stillness of the patient is required to control the
safety of the recanalization. Currently, either a general anesthesia or a sedation can be
performed.
Several studies have shown a trend to superiority of the sedation but none was conducted with
a high level of proof methodology.
The aim of our multicentric randomized controlled trial is to compare sedation and general
anesthesia during intra-arterial thrombectomy for an acute ischaemic stroke in the anterior
cerebral circulation. The main outcome will be the efficacy on the functional neurological
prognosis at 3 months.