Gene Expression Following Short Term Exposure to Neoadjuvant Endocrine Therapy in Invasive Breast Cancer
Status:
Completed
Trial end date:
2009-11-01
Target enrollment:
Participant gender:
Summary
The purpose of this pilot study is to see if taking anastrozole (Arimidex) for 10 days causes
changes in breast cancer cells. Anastrozole (Arimidex) is a drug used in the treatment of a
type of breast cancer that depends on estrogen to grow. This type of breast cancer is called
estrogen receptor positive breast cancer. Anastrozole (Arimidex) works by blocking an enzyme
in your body called aromatase. Aromatase is found in your muscles, fat, liver and in breast
tumors. This enzyme is important for making estrogen in women who are no longer having
menstrual periods. Anastrozole decreases levels of estrogen in the body. We are interested in
seeing if taking anastrozole for 10 days will cause changes in breast cancer cells. We will
study cell processes such as how they make new blood vessels, how quickly the cells multiply,
and how soon they die. We will also study which genes in the breast cancer tissues are turned
on or off by taking anastrozole for 10 days.