Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids
Status:
Completed
Trial end date:
2015-08-01
Target enrollment:
Participant gender:
Summary
The study evaluates the gene-environment interaction of the COMT-genotype on the effects of
the phytocannabinoids delta-9-tetrahydrocannabinol, cannabidiol or a combination of both on
induction of psychotic symptoms, endocannabinoid levels in human body fluids, neuronal
processing, and neural oscillations. In addition the effects of the phytocannabinoids on
lipid levels in serum and cerebrospinal fluid, cognition, neural synchrony and neuronal
processing assessed by EEG and fMRI.