Gender Differences in the Metabolic Effects of Uric Acid
Status:
Withdrawn
Trial end date:
2019-03-13
Target enrollment:
Participant gender:
Summary
Increased stiffening of the heart and blood vessels is a predictor of heart disease.
Stiffening has been found to be greater in women than men, which puts women with poor blood
sugar control at a greater risk for heart disease than men. In women only, a molecule in the
blood called uric acid can be elevated due to diets high in fructose consumption and it is
thought to be a cause of heart and vessel stiffening. From previous research, we have found
that restricting fructose in the diet lowers uric acid more in women than men. There is also
a drug that can be used to lower uric acid. These findings suggest a potential approach to
decrease vessel and heart stiffness in women. The present study will investigate fructose
restriction in the diet and drug treatment to lower uric acid in the blood and its effects on
heart disease risk in women compared to men.