Overview

Gemcitabine and Oxaliplatin as Second-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving gemcitabine together with oxaliplatin works as second-line therapy in treating patients with stage III or stage IV non-small cell lung cancer.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Miami
Treatments:
Gemcitabine
Oxaliplatin
Criteria
DISEASE CHARACTERISTICS:

- Histologically proven stage IIIB or IV non-small cell lung cancer (NSCLC)

- Failed first-line chemotherapy

- Must have received ≥ 1, but no more than 2, prior chemotherapy regimens for stage
IIIB or IV NSCLC

- Prior radiotherapy or surgery for earlier stage disease allowed, provided
target lesions chosen for response assessment have not have been irradiated

- At least 1 unidimensionally measurable lesion with diameter ≥ 20 mm by conventional
methods OR ≥ 10 mm by spiral CT scan

- If a single lesion is identified as the target lesion, histological or
cytological confirmation of this lesion is required

- No symptomatic brain metastases

- Clinically stable brain metastases on a stable dose of (or no longer requiring)
dexamethasone allowed

PATIENT CHARACTERISTICS:

- ECOG performance status 0 or 1

- Absolute neutrophil count ≥ 1,000/mm^3

- Platelet count ≥ 100,000/mm^3

- Bilirubin ≤ 1.5 mg/dL

- AST and ALT ≤ 2.5 times upper limit of normal (ULN) (5 times ULN if liver involvement)

- Creatinine ≤ 1.5 mg/dL

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 2 months after
completion of study treatment

- No history of an acute cardiac or CNS event within the past 6 months, including any of
the following:

- Unstable angina

- Myocardial infarction

- Clinically relevant arrhythmia

- Stroke

- No current clinical evidence of congestive heart failure or unstable coronary artery
disease

- No peripheral neuropathy > grade 1

- No history of hypersensitivity to study drugs

- No serious uncontrolled medical or psychiatric illness, including any of the
following:

- Serious infection

- Interstitial pneumonia

- Extensive and symptomatic fibrosis of the lung

- No other malignancy within the past year, except for squamous cell or basal cell
carcinoma of the skin, carcinoma in situ of the cervix, or superficial transitional
cell carcinoma of the bladder

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- Recovered from prior surgery

- At least 4 weeks since prior cranial radiation for brain metastases

- More than 4 weeks since prior participation in another investigational drug study

- No concurrent immunotherapy