Gemcitabine, Carboplatin, and Lenalidomide for Treatment of Advanced/Metastatic Urothelial Cancer and Other Solid Tumors
Status:
Completed
Trial end date:
2018-07-06
Target enrollment:
Participant gender:
Summary
Background:
- Gemcitabine and carboplatin are chemotherapy drugs used to treat several types of cancer,
including cancer of the pancreas, bladder, ovaries, and lung. Lenalidomide, a drug that
prevents the growth of new blood vessels in tumors, has been approved for treatment of
certain blood cancers, but it has not yet been approved for use in combination with
gemcitabine and carboplatin. Researchers are interested in determining the safest and most
effective dose of this combined form of chemotherapy for solid tumors, particularly for
urothelial cancer (tumors of the bladder, urethra, ureter, or renal pelvis).
Objectives:
- To evaluate the safety and effectiveness of combined lenalidomide, gemcitabine, and
carboplatin as a treatment for solid tumor cancers.
- To evaluate the safety and effectiveness of combined lenalidomide, gemcitabine, and
carboplatin as a treatment for urothelial (bladder) cancer.
Eligibility:
- Individuals at least 18 years of age who have been diagnosed with solid tumors that have
not responded to standard treatments.
- Individuals at least 18 years of age who have been diagnosed with urothelial cancer that
has not responded to standard treatments.
Design:
- Participants will be screened with a physical examination, medical history, blood tests,
and tumor imaging studies.
- Participants with urothelial cancer will receive lenalidomide alone for the first 14
days of a 21-day cycle before starting the first full treatment cycle.
- All participants will receive gemcitabine on days 1 and 8, and carboplatin on day 1
only, of every 21-day treatment cycle. Lenalidomide will be taken daily at home for the
first 14 days of each cycle. Participants will be asked to take aspirin or other
medications to prevent the possibility of blood clots.
- Participants may receive up to six cycles of treatment with this combination. If after
six cycles the cancer has not grown or has shrunk, participants may continue to take
lenalidomide alone for an additional 6 months (total of 12 months of therapy) or until
the cancer recurs.
- Participants will be monitored with blood samples, physical examinations, and tumor
imaging studies through the cycles of treatment.
- After the end of the last treatment cycle, participants will have followup visits every
3 months for the next 18 months, then every 6 months for another 18 months, and then
yearly.