Gemcitabine/Capecitabine/ZD6474 in Advanced Solid Tumors

• Status: Completed
• Trial end date: 2013-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Zactima will be used in this study to determine the highest dose that can be given safely as well as the side effects of Zactima when in combination with two FDA approved drugs; gemcitabine and capecitabine. This combination will be given to patients with advanced solid tumors. Once the highest dose of the combination has been determined, additional patients with biliary cancers (cholangiocarcinomas and gallbladder cancer) and locally advanced or metastatic pancreatic cancer will be treated at the highest determined dose for further studies.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Colorado, Denver
• Collaborator: AstraZeneca
• Treatments: Capecitabine; Gemcitabine

Criteria

Inclusion Criteria:

• Age 18 years or older

• Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 (measure of your ability to perform everyday tasks)

• Life expectancy of at least three months

Blood samples and other testing may apply for further testing of eligibility.

Exclusion Criteria:

• Uncontrolled illness (for example, current infections or heart conditions)

• Abnormal laboratory tests (such as blood or urine testing)

• Pregnant or breastfeeding women

Further exclusion criteria may apply.