The goal of this clinical trial is to evaluate whether balanced gelatin solution is effective and safe for perioperative fluid management in adult patients with sepsis undergoing emergency abdominal surgery.
The main questions it aims to answer are:
Does balanced gelatin solution improve fluid balance within 24 hours after surgery compared with crystalloid solution? Does balanced gelatin solution increase the proportion of patients who achieve hemodynamic stability within 24 hours after surgery? Researchers will also examine secondary outcomes including kidney function, organ dysfunction, postoperative complications, mortality, and length of ICU and hospital stay.
Participants will:
Receive either balanced gelatin solution or crystalloid solution during surgery according to a goal-directed hemodynamic protocol.
Be followed for outcomes up to 90 days after surgery.
Phase:
PHASE4
Details
Lead Sponsor:
Shanghai Zhongshan Hospital
Collaborator:
B. Braun Medical International Trading Company Ltd.