Geisinger Antibiotic Allergy Pilot Program: Assess and Address
Status:
Not yet recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
This is a prospective non-inferiority study to evaluate penicillin allergy history in
patients with reported penicillin allergy, who require penicillin or penicillin-derivative
antibiotic during inpatient admission using a focused questionnaire. A simplified scoring
system will be assigned to patient responses, and the total score will be utilized to
identify low-risk patients that have a minimal risk of allergic reactions on exposure to
penicillin or its derivative. Patients determined to have low risk based on this
questionnaire will be offered a test dose (graded challenge) of amoxicillin in a supervised
setting, and if they tolerate it, penicillin allergy label will be removed from patient's
chart. We hypothesize that at least 95% of low-risk patients will successfully pass the
graded amoxicillin challenge so the penicillin allergy label can be removed from their
charts. A proportion as low as 0.85 would be a good clinical outcome and considered
non-inferior to the expected proportion of 0.95.