Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever

• Status: Completed
• Trial end date: 2015-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators aim to compare two antibiotic treatments for enteric (typhoid) fever. Three hundred patients at Patan Hospital will be enrolled in the study. Patients will be assigned to one of the two treatments by chance and followed for 6 months. The two treatment groups will be compared to see which treatment is more likely to make the patient better.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Oxford University Clinical Research Unit, Vietnam
• Collaborators: Civil Hospital, Nepal; Patan Academy of Health Sciences, Nepal; Patan Hospital, Nepal; University of Oxford
• Treatments: Ceftriaxone; Fluoroquinolones; Gatifloxacin

Criteria

Inclusion Criteria:

• Suspected or culture proven enteric fever

• >= 2 <= 45 years of age

• Fever >= 38°C for >= 4 days

• Informed consent to participate in the study

Exclusion Criteria:

• Pregnancy

• Obtundation

• Shock

• Visible jaundice

• Presence of signs of gastrointestinal bleeding

• Evidence of severe disease

• Diabetes

• History of hypersensitivity to either of the trial drugs

• Known previous treatment with a quinolone antibiotic or 3rd generation cephalosporin or macrolide within one week of hospital admission.