Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse

• Status: Completed
• Trial end date: 2015-01-01
• Target enrollment: 0
• Participant gender: All

Summary

We are testing to see if Galantamine, a learning enhancing medication, will help methadone maintained cocaine abusers with their learning and memory specific to CBT using an innovative CBT computer program.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yale University
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Cocaine; Galantamine; Methadone

Criteria

Inclusion Criteria:

• Males and females between ages of 18 and 50

• Enrolled in RNP methadone program and stable on methadone for at least 3 weeks

• Current cocaine abuse or dependence according to DSM-IV criteria

• No current medical problems and normal ECG

• If female, not currently pregnant or breast feeding and using reliable birth control

• Fluent in English and have at least a 6th grade reading level

• Can commit to 12 weeks of treatment and are willing to be randomized

Exclusion Criteria:

• Current major psychiatric illness including mood, psychotic or anxiety disorder

• History of major medical illnesses including asthma, chronic obstructive lung disease, gastrointestinal ulcer, hepatic or renal impairment, cardiac rhythm disturbances

• Use of medications including beta blockers and NASAIDs

• Known allergy to Galantamine