Galantamine Augmentation of Escitalopram for Treatment of Depression
Status:
Terminated
Trial end date:
2005-09-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate whether the addition of galantamine to a commonly
used antidepressant, escitalopram (Lexapro), will be useful in the treatment of memory and
other thinking problems that are frequently seen in depression. At present, galantamine is
approved for use in the treatment of Alzheimer's disease or dementia, but not for use for the
treatment of depression in younger patients.
Possible genetic effects of depressed individuals will also be studied. This study is
involved in collecting blood from patients with depression. DNA, the genetic material in our
cells, will be obtained from these blood samples. The DNA will be studied to determine the
contribution of different genes to the development of depression. These blood samples are
extremely useful to researchers who are trying to determine the genetic risk factors that may
lead to depression.