Gabapentin and Donepezil Combination on Experimental Human Pain Models
Status:
Completed
Trial end date:
2012-07-03
Target enrollment:
Participant gender:
Summary
This study will compare the effects of gabapentin alone, and gabapentin + donepezil given
together in two types of experimental electrical pain tests in up to 48 healthy male subjects
(after 24 recruited in the first cohort an interim analysis will be performed).
The study is a randomized, double blind, placebo controlled, 3 was cross-over design study
with incomplete block design and 4 treatment options. Placebo, gabapentin alone (lower dose
and higher dose) or gabapentin (lower dose) with donepezil.